The 2025-26 NFL season kicks off tonight with a high-stakes showdown on NBC as the Philadelphia Eagles host the Dallas Cowboys at Lincoln Financial Field. Fresh off a dominant Super Bowl run, the Eagles enter the new season with confidence, having dropped just three games last year.
Meanwhile, the Cowboys are looking to rebound after a brutal 2024 campaign that saw them finish with only seven wins and miss the postseason. Their defense also suffered a significant blow in the offseason when standout linebacker Micah Parsons was traded to the Green Bay Packers, significantly altering the team’s dynamics.
In addition to the kickoff game tonight, there are a total of 16 games this weekend, with several notable matchups, including the Chiefs vs. the Chargers, Ravens vs. the Bills, and the Vikings vs. the Bears (Monday). Football betting fans will also enjoy the numerous ways you can bet on the NFL online with future odds, game lines, live odds, props, and more.
Below, we will discuss some of the game lines posted for this weekend, along with numerous other ways you can wager on professional football with legal football betting apps.
Cowboys vs. Eagles
The Eagles are leading just about every future odds they are included in, and the game lines provided for them against the Cowboys show they are 8-point favorites. The Cowboys are finally healthy, but the Eagles are stacked on both sides of the ball. Personally, I believe this game will not be close at all. I expect the Eagles to pull away in the second half.
Dallas Cowboys at Philadelphia Eagles
- Point Spread: Cowboys +8.0, Eagles -8.0
- Moneyline: Cowboys +335, Eagles -450
- Over/Under: 48.0
Chiefs vs. Chargers
The Chiefs are looking to avenge their Super Bowl defeat, and a win in week one could soften the blow. After losing big to the Eagles in Super Bowl LIX, I expect the Chiefs to come out with something to prove. However, the Chargers are also looking to lead the AFC West division with their group of young, talented athletes.
Our staff at footballbetting.legal is split on the outcome of this game, with most leaning towards a Chiefs victory. Personally, I think the Chiefs losing streak continues with a Chargers close win.
Kansas City Chiefs vs. Los Angeles Chargers
- Point Spread: Chiefs -3.0, Eagles +3.0
- Moneyline: Chiefs -170, Eagles +145
- Over/Under: 46.5
Ravens vs. Bills
The Sunday night game will feature the Baltimore Ravens as they return to Buffalo to face the Bills. Last year, both teams made the playoffs but fell short of the big game. This game is going to be too close to call, as a few plays could dramatically shape the outcome of this game. Odds favor the Ravens by 1.5 points.
Baltimore Ravens vs. Buffalo Bills
- Point Spread: Ravens -1.5, Bills +1.5
- Moneyline: Ravens -120, Bills EVEN
- Over/Under: 50.5