Betting on NFL odds and preseason matchups with online football betting sites requires a different mindset than wagering during the regular season. Mainly, because starters often play limited snaps or not at all. However, the key to preseason gambling success is understanding team depth charts, coaching tendencies, and quarterback rotations.
Offshore football betting sites typically offer broader access to more players and lower age restrictions (often 18+), making them appealing to bettors across the U.S. who may not have access to domestic sportsbooks. These sites also tend to post lines early and offer more bettor-friendly odds, especially for preseason matchups.
By The Numbers
Strategically, bettors should focus on teams with strong backup quarterbacks and good coaching staffs. For example, betting trends reported by MSN from Week 1 of the 2025 preseason showed underdogs going 12-4 against the spread and overs hitting in 14 of 16 games.
This stat suggests that scoring may be higher than expected, especially in games featuring quarterback battles or deep offensive rosters. Monitoring NFL reports and coach interviews can also provide valuable insights into playing time and game plans that could affect a team’s performance.
Ultimately, the preseason is less about winning and more about on-field position battles, making it a prime opportunity for informed bettors to gain an edge.
Week 2 – NFL Preseason Odds
Below are the current game line odds for the second week of preseason games leading up to the 2025 NFL schedule. This weekend, there are games on Friday, Saturday, Sunday, and Monday featuring all 32 teams.
While this weekend, we may see a few more starters take the field, it is doubtful that many will play a significant amount of time.
August 15, 2025
Tennessee Titans vs. Atlanta Falcons (7:00 PM)
- Spread: Titans +5.0 (-110), Falcons -5.0 (-110)
- Moneyline: Titans +190, Falcons -230
- Total: Over 37.5 (-110), Under 37.5 (-110)
Kansas City Chiefs vs. Seattle Seahawks (10:00 PM)
- Spread: Chiefs -3.0 (-110), Seahawks +3.0 (-110)
- Moneyline: Chiefs -165, Seahawks +140
- Total: Over 41.0 (-110), Under 41.0 (-110)
August 16, 2025
Carolina Panthers vs. Houston Texans (1:00 PM)
- Spread: Panthers +2.0 (-110), Texans -2.0 (-110)
- Moneyline: Panthers +110, Texans -130
- Total: Over 37.5 (-110), Under 37.5 (-110)
Cleveland Browns vs. Philadelphia Eagles (1:00 PM)
- Spread: Browns +1.5 (-110), Eagles -1.5 (-110)
- Moneyline: Browns +105, Eagles -125
- Total: Over 37.5 (-110), Under 37.5 (-110)
Green Bay Packers vs. Indianapolis Colts (1:00 PM)
- Spread: Packers +6.0 (-110), Colts -6.0 (-110)
- Moneyline: Packers +215, Colts -260
- Total: Over 39.5 (-110), Under 39.5 (-110)
Miami Dolphins vs. Detroit Lions (1:00 PM)
- Spread: Dolphins -4.0 (-110), Lions +4.0 (-110)
- Moneyline: Dolphins -210, Lions +175
- Total: Over 36.0 (-115), Under 36.0 (-105)
New England Patriots vs. Minnesota Vikings (1:00 PM)
- Spread: Patriots +1.0 (-120), Vikings -1.0 (EVEN)
- Moneyline: Patriots -110, Vikings -110
- Total: Over 38.5 (-110), Under 38.5 (-110)
San Francisco 49ers vs. Las Vegas Raiders (4:00 PM)
- Spread: 49ers +6.0 (-115), Raiders -6.0 (-105)
- Moneyline: 49ers +210, Raiders -250
- Total: Over 40.5 (-110), Under 40.5 (-110)
Baltimore Ravens vs. Dallas Cowboys (7:00 PM)
- Spread: Ravens -3.0 (-105), Cowboys +3.0 (-115)
- Moneyline: Ravens -150, Cowboys +130
- Total: Over 36.5 (-115), Under 36.5 (-105)
Los Angeles Chargers vs. Los Angeles Rams (7:00 PM)
- Spread: Chargers -3.5 (-110), Rams +3.5 (-110)
- Moneyline: Chargers -195, Rams +165
- Total: Over 36.5 (-115), Under 36.5 (-105)
New York Jets vs. New York Giants (7:00 PM)
- Spread: Jets +3.0 (-110), Giants -3.0 (-110)
- Moneyline: Jets +140, Giants -165
- Total: Over 38.5 (-110), Under 38.5 (-110)
Tampa Bay Buccaneers vs. Pittsburgh Steelers (7:00 PM)
- Spread: Buccaneers -2.5 (-120), Steelers +2.5 (EVEN)
- Moneyline: Buccaneers -150, Steelers +130
- Total: Over 37.5 (-110), Under 37.5 (-110)
Arizona Cardinals vs. Denver Broncos (9:30 PM)
- Spread: Cardinals +6.5 (-110), Broncos -6.5 (-110)
- Moneyline: Cardinals +225, Broncos -275
- Total: Over 40.0 (-110), Under 40.0 (-110)
August 17, 2025
Jacksonville Jaguars vs. New Orleans Saints (1:00 PM)
- Spread: Jaguars -1.5 (-105), Saints +1.5 (-115)
- Moneyline: Jaguars -120, Saints EVEN
- Total: Over 38.5 (-110), Under 38.5 (-110)
Buffalo Bills vs. Chicago Bears (8:00 PM)
- Spread: Bills +2.0 (-115), Bears -2.0 (-105)
- Moneyline: Bills +110, Bears -130
- Total: Over 38.5 (-110), Under 38.5 (-110)
August 18, 2025
Cincinnati Bengals vs. Washington Commanders (8:00 PM)
- Spread: Bengals -3.0 (-115), Commanders +3.0 (-105)
- Moneyline: Bengals -175, Commanders +150
- Total: Over 41.5 (-110), Under 41.5 (-110)